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Designed to replace the 375 Weatherby Magnum, deep penetration and bone smashing power are the calling cards of the 378. Its massive case holds so much powder that Federal designed its super-hot 215 primer to handle the load. Roy Weatherby’s 378 delivers 34 percent more energy at the muzzle than the powerful 375 H&H Magnum. Since 1955, the 378 has become one of the world’s most popular cartridges for the largest of big game animals.